In a large skillet, cook ground beef and onions over medium heat until meat is no longer pink. Add garlic; cook 1 minute longer. Drain. Add the beans, barbecue sauce, brown sugar, ketchup and mustard. Simmer for 5 minutes or until heated through.
Transfer to a greased 11x7-in. baking dish. Separate biscuits and cut in half; arrange over beef mixture. Bake, uncovered, at 400° for 18 minutes or until biscuits are golden brown. Sprinkle with cheese; bake 2-3 minutes longer or until cheese is melted.
Editor's Note: This recipe was tested with Pillsbury buttermilk biscuits, which has six biscuits in a 4-1/2 ounce tube.